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Research Interests

Carbohydrates are a class of naturally occurring compounds involved in important biological processes such as immune response, tumour development, and bacterial infections. Pure and structurally well-defined glycans are needed for the in-depth understanding of these mechanisms as well as for the elaboration of sugar-based medicines. Glycans are often found as highly complex heterogeneous structures complicating their isolation from biological sources. Therefore, chemical synthesis stands as a method of choice for the preparation of pure glycans. The long-term goals of our research program are:

The general objective is therefore twofold. It consists, on the one hand, in advancing fundamental knowledge in carbohydrate chemistry and, on the other hand, in generating biomolecules derived from sugars with potential applications in the biomedical field. In order to meet these general objectives, several research projects have emerged in my team in recent years. We have built an expertise in the synthesis of complex oligosaccharides from resistant pathogenic bacteria to create glycoconjugate vaccines. We are working with our microbiologist colleagues to find alternatives to antibiotics from natural compounds and their mimetics. We are developing innovative synthetic routes for the preparation of marine and bacterial glycolipids, and natural products with intriguing molecular structures, which could find application as surfactants or therapeutics. We are also interested in the discovery of non-toxic vaccine adjuvants based on carbohydrate-based natural products readily available from plant residues. The implementation of these research projects requires a vast network of collaborators that we have put in place in recent years.

Examples of active research projects:

Five most important papers:

Cloutier, M.; Lavoie, S.; Gauthier, C.* C7 epimerization of benzylidene-protected β-D-idopyranosides brings structural insights into idose conformational flexibility. J. Org. Chem. 2022, 87, 12932-12953 (link)

Muru, K.; Cloutier, M.; Provost-Savard, A.; Di Cintio, S.; Burton, O.; Cordeil, J.; Groleau, M.-C.; Legault, J.; Déziel, E.; Gauthier, C.* Total synthesis of a chimeric glycolipid bearing the partially acetylated backbone of sponge-derived agminoside E. J. Org. Chem. 2021, 21, 15357-15375 (link)

Cloutier, M.; Prévost, M.-J.; Lavoie, S.; Feroldi, T.; Piochon, M.; Groleau, M.-C.; Legault, J.; Villaume, S.; Crouzet, J.; Dorey, S.; De Rienzo, M. A. D.; Déziel, E.; Gauthier, C.* Total synthesis, isolation, surfactant properties, and biological evaluation of ananatosides and related macrodilactone-containing rhamnolipids. Chem. Sci. 2021, 12, 7533-7546 (link)

Gamboa Marin, O. J.; Hussain, N.; Ravicoularamin, G.; Ameur, N.; Gormand, P.; Sauvageau, J.; Gauthier, C.* Total synthesis of 6-amino-2,6-dideoxy-
α-Kdo from D-mannose. Org. Lett. 2020, 22, 5783-5788. (link)

Tamigney Kenfack, M.; Mazur, M.; Nualnoi, T.; Shaffer, T. L.; Ngassimou, A.; Blériot, Y.; Marrot, J.; Marchetti, R.; Sintiprungrat, K.; Chantratita, N.; Silipo, A.; Molinaro, A.; AuCoin, D. P.; Burtnick, M. N.; Brett, P. J.; Gauthier, C.*
Deciphering minimal antigenic epitopes associated with Burkholderia pseudomallei and Burkholderia mallei lipopolysaccharide O-antigens. Nat. Commun. 2017, 8, 115 (link)

Scientific Collaborators


Prof. Éric Déziel, INRS
Prof. Charles M. Dozois, INRS
Prof. Alain Lamarre, INRS
Prof. Charles Ramassamy, INRS
Prof. Salim Timo Islam, INRS
Prof. Serge Lavoie, UQAC
Prof. Jean Legault, UQAC
Prof. André Pichette, UQAC
Prof. Jérôme Alsaraff


Prof. Ralph Pantophlet, Simon-Fraser University
Prof. Samy Cecioni, Université de Montréal
Prof. Adnane Sellam, Université de Montréal


Prof. David P. AuCoin, University of Nevada
Prof. Paul J. Brett, University of Nevada
Prof. Mary N. Burtnick, University of Nevada
Prof. Josephine Chandler, The University of Kansas
Prof. Narisara Chantratita, Mahidol University
Dr Mayri A. D. de Rienzo, Liverpool John Moores University
Prof. Stephan Dorey, Université de Reims Champagne-Ardenne
Prof. Antonio Molinaro, Universtà du Napoli Federico II
Dr Laurence A. Mulard, Institut Pasteur
Prof. Alba Silipo, Universtà du Napoli Federico II
Prof. Stéphane Vincent, Université de Namur


UQAC – Université du Québec à Chicoutimi

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