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Research Interests

Carbohydrates are a class of naturally occurring compounds involved in important biological processes such as immune response, tumour development, and bacterial infections. Pure and structurally well-defined glycans are needed for the in-depth understanding of these mechanisms as well as for the elaboration of sugar-based medicines. Glycans are often found as highly complex heterogeneous structures complicating their isolation from biological sources. Therefore, chemical synthesis stands as a method of choice for the preparation of pure glycans. The long-term goals of our research program are:

  1. To develop novel methodologies and synthetic routes allowing access to carbohydrate-based compounds from natural origin;
  2. To assess the pharmacological potential of these synthetic carbohydrate-based compounds as therapeutics and prophylactics.
The general objective is therefore twofold. It consists, on the one hand, in advancing fundamental knowledge in carbohydrate chemistry and, on the other hand, in generating biomolecules derived from sugars with potential applications in the biomedical field. In order to meet these general objectives, several research projects have emerged in my team in recent years. We have built an expertise in the synthesis of complex oligosaccharides from resistant pathogenic bacteria to create glycoconjugate vaccines. We are working with our microbiologist colleagues to find alternatives to antibiotics from natural compounds and their mimetics. We are developing innovative synthetic routes for the preparation of marine and bacterial glycolipids, and natural products with intriguing molecular structures, which could find application as surfactants or therapeutics. We are also interested in the discovery of non-toxic vaccine adjuvants based on carbohydrate-based natural products readily available from plant residues. The implementation of these research projects requires a vast network of collaborators that we have put in place in recent years.

Examples of active research projects:


Five most important papers:

Cloutier, M.; Prévost, M.-J.; Lavoie, S.; Feroldi, T.; Piochon, M.; Groleau, M.-C.; Legault, J.; Villaume, S.; Crouzet, J.; Dorey, S.; De Rienzo, M. A. D.; Déziel, E.; Gauthier, C.* Total synthesis, isolation, surfactant properties, and biological evaluation of ananatosides and related macrodilactone-containing rhamnolipids. Chem. Sci. 2021, 12, 7533-7546 (link)

Cloutier, M.; Gauthier, C.* Progress towards the development of glycan-based vaccines against campylobacteriosis. ACS Infect. Dis. 2021, 7, 969-986 (link)

Gamboa Marin, O. J.; Hussain, N.; Ravicoularamin, G.; Ameur, N.; Gormand, P.; Sauvageau, J.; Gauthier, C.* Total synthesis of 6-amino-2,6-dideoxy-
α-Kdo from D-mannose. Org. Lett. 2020, 22, 5783-5788. (link)

Tamigney Kenfack, M.; Mazur, M.; Nualnoi, T.; Shaffer, T. L.; Ngassimou, A.; Blériot, Y.; Marrot, J.; Marchetti, R.; Sintiprungrat, K.; Chantratita, N.; Silipo, A.; Molinaro, A.; AuCoin, D. P.; Burtnick, M. N.; Brett, P. J.; Gauthier, C.*
Deciphering minimal antigenic epitopes associated with Burkholderia pseudomallei and Burkholderia mallei lipopolysaccharide O-antigens. Nat. Commun. 2017, 8, 115 (link)

Mazur, M.; Barycza, B.; Andriamboavonjy, H.; Lavoie, S.; Tamigney Kenfack, M.; Laroussarie, A.; Blériot, Y.; Gauthier, C.*
4'-Methoxyphenacyl-assisted synthesis of β-Kdo glycosides. J. Org. Chem. 2016, 81, 10585-10599 (link)


Scientific Collaborators

Local:

Prof. Éric Déziel, INRS
Prof. Charles M. Dozois, INRS
Prof. Alain Lamarre, INRS
Prof. Charles Ramassamy, INRS
Prof. Salim Timo Islam, INRS

National:

Prof. Serge Lavoie, UQAC
Prof. Jean Legault, UQAC
Prof. André Pichette, UQAC
Dr. Janelle Sauvageau, CNRC
Prof. Adnane Sellam, Université de Montréal
Prof. Chris Whitfield, University of Guelph

International:

Prof. David P. AuCoin, University of Nevada
Prof. Paul J. Brett, University of Nevada
Prof. Mary N. Burtnick, University of Nevada
Prof. Josephine Chandler, The University of Kansas
Prof. Narisara Chantratita, Mahidol University
Dr Mayri A. D. de Rienzo, Liverpool John Moores University
Prof. Stephan Dorey, Université de Reims Champagne-Ardenne
Prof. Antonio Molinaro, Universtà du Napoli Federico II
Dr Laurence A. Mulard, Institut Pasteur
Prof. Alba Silipo, Universtà du Napoli Federico II
Prof. Stéphane Vincent, Université de Namur


Funding

L'INRS fête ses 50 ans!
Accueil - RIIP - Réseau International des Instituts Pasteur

Accueil • Fondation Armand-Frappier - Ensemble, soutenons l'innovation en  santé publique

Fonds de la recherche scientifique — Wikipédia

CERMO-FC – RISUQ
CIHR

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NSERC

ANR

DGA

CNRS

IC2MP

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