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Research Interests

Carbohydrates are a class of naturally occurring compounds involved in important biological processes such as immune response, tumour development and bacterial infections. Pure and structurally well-defined glycans are urgently needed for the in-depth understanding of these mechanisms as well as for the elaboration of sugar-based medicines. Glycans are often found as highly complex heterogeneous structures complicating their isolation from biological sources. Therefore, chemical synthesis stands as a method of choice for the preparation of pure glycans. Two major challenges are still facing carbohydrate chemistry today, i.e. the cumbersome multiple protection/glycosylation steps needed for the synthesis of high molecular weight glycans, and the lack of general procedures for glycosidic bonds formation. Along these lines, the long-term goals of our research program are three-fold: 1) the development of novel one-pot protection/glycosylation methodologies aiming at streamlining the synthesis of oligosaccharides and their derivatives; 2) the development of efficient and stereoselective glycosylation reactions for the synthesis of biologically important glycosidic linkages found in the polysaccharides of pathogenic bacteria; and 3) the application of these procedures to the total synthesis of complex oligosaccharides and glycolipids in the context of developing vaccines, diagnostics and therapeutic agents.

List of active research projects:

Below, please find a list of recent research projects and related publications. For more details about our research interests, please visit the publications section.

1) Development of new glycosylation methodologies en route toward antibacterial vaccines

Representative publications:

Tamigney Kenfack, M.; Mazur, M.; Nualnoi, T.; Shaffer, T. L.; Ngassimou, A.; Blériot, Y.; Marrot, J.; Marchetti, R.; Sintiprungrat, K.; Chantratita, N.; Silipo, A.; Molinaro, A.; AuCoin, D. P.; Burtnick, M. N.; Brett, P. J.; Gauthier, C.* Nature Communications 2017, 8, 115 (*Corresponding author) (link) (supporting information)

Mazur, M.; Barycza, B.; Andriamboavonjy, H.; Lavoie, S.; Tamigney Kenfack, M.; Laroussarie, A.; Blériot, Y.; Gauthier, C.* The Journal of Organic Chemistry
2016, 81, 10585-10599 (*Corresponding author) (Selected as a "Featured Article" & Cover Page of Issue #22) (link) (supporting information)

Laroussarie, A.; Barycza, B.; Andriamboavonjy, H.; Tamigney Kenfack, M.; Blériot, Y.; Gauthier, C.* The Journal of Organic Chemistry 2015, 80, 10386-10396 (*Corresponding author) (link) (supporting information)

Tamigney Kenfack, M.; Blériot, Y.; Gauthier, C.* The Journal of Organic Chemistry 2014, 79, 4615-4634 (*Corresponding author) (link) (supporting information) (video)

2) Isolation and synthesis of bioactive natural products

Representative publications:

Simard, F.; Gauthier, C.; Legault, J.; Lavoie, S.; Mshvildadze, V.; Pichette, A. Bioorganic & Medicinal Chemistry 2016, 24, 4188-4198 (link) (supporting information)

Lavoie, S.; Gauthier, C.; Mshvildadze, V.; Legault, J.; Roger, B.; Pichette, A. Journal of Natural Products 2015, 78, 2896-2907 (These authors contributed equally) (link) (supporting information)

Sylla, B.; Gauthier, C.; Legault, J.; Fleury, P.-Y.; Lavoie, S.; Mshvildadze, V.; Muzashvili, T.; Kemertelidze, E.; Pichette, A. Carbohydrate Research 2014, 398, 80-89 (*These authors contributed equally) (link) (supporting information)

Lavoie, S.; Legault, J.; Gauthier, C.; Mshvildadze, V.; Mercier, S.; Pichette, A. Organic Letters 2012, 14, 1504-1507 (link) (supporting information)

Scientific Collaborations

Prof. Paul J. Brett (South Alabama University, Mobile, United States)

Prof. Mary N. Burtnick (South Alabama University, Mobile, United States)

Prof. David P. AuCoin (Nevada School of Medicine, Reno, United States)

Prof. Antonio Molinaro (University of Federico II, Naples, Italy)

Prof. Alba Silipo (University of Federico II, Naples, Italy)

Prof. Daniel Grenier (Université Laval, Québec City, Canada)

Prof. Eric Déziel (INRS-Institut Armand-Frappier, Laval, Canada)

Prof. Charles Ramassamy (INRS-Institut Armand-Frappier, Laval, Canada)

Prof. André Pichette (Université du Québec à Chicoutimi, Saguenay, Canada)

Prof. Jean Legault (Université du Québec à Chicoutimi, Saguenay, Canada)

Prof. Vakhtang Mshvildadze (Université du Québec à Chicoutimi, Saguenay, Canada)


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